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- Title
Variations in Excision Repair of UVB-Induced Pyrimidine Dimers in DNA of Human Skin in Situ.
- Authors
Freeman, Steven E.
- Abstract
The excision repair kinetics of UVB (280-320 nm)*-induced pyrimidine dimers in DNA of human skin in situ was determined for seventeen volunteers using a dimer-specific endonuclease from <em>Micrococcus luteus</em> in conjunction with agarose gel electrophoresis. Removal of pyrimidine dimers from human skin could be detected within 6 h after irradiation and the average half-life for removal of pyrimidine dimers was 11.0 h (± 4.3 h). However, there was significant inter-individual variability of repair as indicated by a half-life coefficient of variation of 38%.
- Subjects
DERMATOLOGIC surgery; SURGICAL excision; OPERATIVE surgery; DIMERS; OLIGOMERS; DNA
- Publication
Journal of Investigative Dermatology, 1988, Vol 90, Issue 6, p814
- ISSN
0022-202X
- Publication type
Article
- DOI
10.1111/1523-1747.ep12462039