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- Title
Influence of azathioprine (Imuran) on in vitro immune function in multiple sclerosis.
- Authors
Oger, Joel J.-F.; Antel, Jack P.; Kuo, Han Hwa; Arnason, Barry G. W.
- Abstract
In vitro immune function was assessed in patients with multiple sclerosis (MS) who were receiving Imuran therapy, in untreated MS patients, and in controls. In untreated stable MS patients, concanavalin A (Con A)-driven mitogenic reactivity (T effector function) and Con A-induced suppressor activity were modestly reduced compared to controls; pokeweed mitogen-induced immunoglobulin G (IgG) secretion was increased. Untreated patients with active MS demonstrated high levels of IgG secretion and marked decreases in suppressor activity. In Imuran-treated patients, Con A mitogenic responses and suppressor activity were comparable to those observed in untreated stable patients, and IgG secretion was reduced. The results in the treated patients likely reflect a direct effect of Imuran on B cell function rather than an indirect effect mediated via suppressor cells.
- Publication
Annals of Neurology, 1982, Vol 11, Issue 2, p177
- ISSN
0364-5134
- Publication type
Article
- DOI
10.1002/ana.410110211