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- Title
RNF43 is frequently mutated in colorectal and endometrial cancers.
- Authors
Giannakis, Marios; Van Allen, Eliezer M; Hahn, William C; Garraway, Levi A; Fuchs, Charles S; Hodis, Eran; Jasmine Mu, Xinmeng; Rosenbluh, Joseph; Yamauchi, Mai; Qian, Zhi Rong; Cibulskis, Kristian; Saksena, Gordon; Lawrence, Michael S; Gabriel, Stacey B; Nishihara, Reiko; Lander, Eric S; Getz, Gad; Ogino, Shuji
- Abstract
We report somatic mutations of RNF43 in over 18% of colorectal adenocarcinomas and endometrial carcinomas. RNF43 encodes an E3 ubiquitin ligase that negatively regulates Wnt signaling. Truncating mutations of RNF43 are more prevalent in microsatellite-unstable tumors and show mutual exclusivity with inactivating APC mutations in colorectal adenocarcinomas. These results indicate that RNF43 is one of the most commonly mutated genes in colorectal and endometrial cancers.
- Subjects
ENDOMETRIAL cancer; ENDOMETRIAL tumors; UBIQUITIN ligases; GENETIC mutation; MELANOMA; DNA
- Publication
Nature Genetics, 2014, Vol 46, Issue 12, p1264
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/ng.3127