We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis.
- Authors
King, Jennifer C.; Jin Xu; Wongvipat, John; Hieronymus, Haley; Carver, Brett S.; Leung, David H.; Taylor, Barry S.; Sander, Chris; Cardiff, Robert D.; Couto, Suzana S.; Gerald, William L.; Sawyers, Charles L.
- Abstract
The TMPRSS2-ERG fusion, present in approximately 50% of prostate cancers, is less common in prostatic intraepithelial neoplasia (PIN), raising questions about whether TMPRSS2-ERG contributes to disease initiation. We identified the translational start site of a common TMPRSS2-ERG fusion and showed that transgenic TMPRSS2-ERG mice develop PIN, but only in the context of PI3-kinase pathway activation. TMPRSS2-ERG–positive human tumors are also enriched for PTEN loss, suggesting cooperation in prostate tumorigenesis.
- Subjects
GENOMICS; CARCINOGENESIS; PROSTATE cancer; TUMORS; FOCAL adhesion kinase; TRANSGENIC mice; GENETIC research
- Publication
Nature Genetics, 2009, Vol 41, Issue 5, p524
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/ng.371