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- Title
Human papillomavirus and oropharynx cancer: Biology, detection and clinical implications.
- Authors
Allen, Clint T.; Lewis, Jr., James S.; El-Mofty, Samir K.; Haughey, Bruce H.; Nussenbaum, Brian
- Abstract
Objectives: To review evidence for the role of human papillomavirus (HPV) in the etiology of oropharyngeal cancers, methods of viral detection, and the resulting clinical implications. Study Design: Contemporary review. Methods: Published journal articles identified through PubMed and conference proceedings were reviewed. Results: HPV-associated squamous cell carcinomas represent a distinct disease entity from carcinogen-associated squamous cell carcinomas. HPV oncoproteins lead to mucosal cell transformation through well-defined mechanisms. Different methods of detecting HPV exist with variable levels of sensitivity and specificity for biologically active virus. Although virus is detected in a number of head and neck subsites, studies demonstrate improved outcomes in HPV-associated carcinoma of the oropharynx only. The cell cycle regulatory protein p16 is upregulated by biologically active HPV and serves as a biomarker of improved response to therapy. Conclusions: HPV-associated squamous cell carcinoma of the oropharynx is a biologically distinct entity from carcinogen-associated carcinoma. Understanding the molecular mechanisms behind the improved outcomes in patients with HPV-associated oropharyngeal carcinoma may lead to novel therapeutics for patients with carcinogen-associated carcinomas. Laryngoscope, 2010
- Subjects
PAPILLOMAVIRUSES; PHARYNGEAL cancer; SQUAMOUS cell carcinoma; CARCINOGENESIS; CELL cycle
- Publication
Laryngoscope, 2010, Vol 120, Issue 9, p1756
- ISSN
0023-852X
- Publication type
Article
- DOI
10.1002/lary.20936