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- Title
Psychopathological characteristics in patients with arginine vasopressin deficiency (central diabetes insipidus) and primary polydipsia compared to healthy controls.
- Authors
Atila, Cihan; Beck, Julia; Refardt, Julie; Erlic, Zoran; Drummond, Juliana B; Sailer, Clara O; Liechti, Matthias E; Rocha, Beatriz Santana Soares; Beuschlein, Felix; Winzeler, Bettina; Christ-Crain, Mirjam
- Abstract
Objective Distinguishing arginine vasopressin deficiency (AVP-D; central diabetes insipidus) from primary polydipsia (PP), commonly referred to as psychogenic polydipsia, is challenging. Psychopathologic findings, commonly used for PP diagnosis in clinical practice, are rarely evaluated in AVP-D patients, and no comparative data between the two conditions currently exist. Design Data from two studies involving 82 participants [39 AVP-D, 28 PP, and 15 healthy controls (HC)]. Methods Psychological evaluations were conducted using standardized questionnaires measuring anxiety [State-Trait Anxiety Inventory (STAI)], alexithymia [Toronto Alexithymia Scale (TAS-20)], depressive symptoms (Beck's Depression Inventory-II (BDI-II), and overall mental health [Short Form-36 Health Survey (SF-36)]. Higher STAI, TAS-20, and BDI-II scores suggest elevated anxiety, alexithymia, and depression, while higher SF-36 scores signify better overall mental health. Results Compared to HC, patients with AVP-D and PP showed higher levels of anxiety (HC 28 points [24–31] vs AVP-D 36 points [31–45]; vs PP 38 points [33–46], P <.01), alexithymia (HC 30 points [29–37] vs AVP-D 43 points [35–54]; vs PP 46 points [37–55], P <.01), and depression (HC 1 point [0–2] vs AVP-D 7 points [4–14]; vs PP 7 points [3–13], P <.01). Levels of anxiety, alexithymia, and depression showed no difference between both patient groups (P =.58, P =.90, P =.50, respectively). Compared to HC, patients with AVP-D and PP reported similarly reduced self-reported overall mental health scores (HC 84 [68–88] vs AVP-D 60 [52–80], P =.05; vs PP 60 [47–74], P <.01). Conclusion This study reveals heightened anxiety, alexithymia, depression, and diminished overall mental health in patients with AVP-D and PP. The results emphasize the need for careful interpretation of psychopathological characteristics to differentiate between AVP-D and PP.
- Subjects
DIABETES insipidus; ALEXITHYMIA; VASOPRESSIN; POLYDIPSIA; STATE-Trait Anxiety Inventory; MENTAL depression; PSYCHOLOGICAL techniques
- Publication
European Journal of Endocrinology, 2024, Vol 190, Issue 5, p354
- ISSN
0804-4643
- Publication type
Article
- DOI
10.1093/ejendo/lvae040