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- Title
Changes in thyroid function parameters 3 months after allogeneic and autologous hematopoietic stem cell transplantation in children.
- Authors
Lebbink, Chantal A.; Bresters, Dorine; Tersteeg, Joni P. B.; den Bos, Cor van; Dierselhuis, Miranda P.; Lentjes, Eef G. W. M.; Verrijn Stuart, Annemarie A.; Fiocco, Marta; Tissing, Wim J. E.; van Santen, Hanneke M.
- Abstract
Background: Thyroid dysfunction (hypo- and hyperthyroidism) has been reported as a late effect after hematopoietic stem cell transplantation (HSCT) in children. Short-term effects of HSCT on thyroid function parameters are, however, unclear. Methods: We prospectively evaluated thyroid function parameters before and 3 months after HSCT in all children (<21 years) who underwent HSCT during a 2-year period in the Princess Máxima Center, the Netherlands. Results: Among 72 children, none had thyroidal hypothyroidism or hyperthyroidism 3 months after HSCT. Changes in thyroid function parameters (either aberrant thyroid-stimulating hormone [TSH] or free thyroxine [FT4] concentrations) were found in 16% before and in 10% 3 months after HSCT. Reverse triiodothyronine (rT3) was found elevated in 9.3% before and in 37% 3 months after HSCT, which could be related to poor physical condition. An individual decline in FT4 concentration of ≥20% was found in 10.5% (6/57) 3 months after HSCT. Conclusion: In conclusion, thyroidal hypo- and hyperthyroidism are very rare 3 months after HSCT. These results indicate that surveillance for hypo- and hyperthyroidism may start later in time. The changes in thyroid function parameters found 3 months after HSCT might reflect euthyroid sick syndrome.
- Subjects
THYROID gland function tests; HEMATOPOIETIC stem cell transplantation
- Publication
European Journal of Endocrinology, 2023, Vol 188, Issue 6, p503
- ISSN
0804-4643
- Publication type
Article
- DOI
10.1093/ejendo/lvad058