We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Presenting native-like HIV-1 envelope trimers on ferritin nanoparticles improves their immunogenicity.
- Authors
Sliepen, Kwinten; Ozorowski, Gabriel; Burger, Judith A.; van Montfort, Thijs; Stunnenberg, Melissa; LaBranche, Celia; Montefiori, David C.; Moore, John P.; Ward, Andrew B.; Sanders, Rogier W.
- Abstract
Background: Presenting vaccine antigens in particulate form can improve their immunogenicity by enhancing B cell activation. Findings: We describe ferritin-based protein nanoparticles that display multiple copies of native-like HIV-1 envelope glycoprotein trimers (BG505 SOSIP.664). Trimer-bearing nanoparticles were significantly more immunogenic than trimers in both mice and rabbits. Furthermore, rabbits immunized with the trimer-bearing nanoparticles induced significantly higher neutralizing antibody responses against most tier 1A viruses, and higher responses (but not significantly), to several tier 1B viruses and the autologous tier 2 virus than when the same trimers were delivered as soluble proteins. Conclusions: This or other nanoparticle designs may be practical ways to improve the immunogenicity of envelope glycoprotein trimers.
- Subjects
VACCINES; ANTIGENS; B cells; FERRITIN; GLYCOPROTEINS
- Publication
Retrovirology, 2015, Vol 12, Issue 1, p1
- ISSN
1742-4690
- Publication type
Article
- DOI
10.1186/s12977-015-0210-4