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- Title
Local anaesthetic systemic toxicity following oral ingestion in a child: Revisiting dibucaine.
- Authors
Dias, Raylene; Dave, Nandini; Tullu, Milind S.; Deshmukh, Chandrahas T.
- Abstract
Dibucaine, a potent and toxic local anaesthetic, although currently withdrawn by the United States Food and Drug Administration for use as a spinal anaesthetic, continues to remain available in many over-the-counter topical formulations. Systemic toxicity following oral ingestion of local anaesthetics is rare. We report a case of accidental ingestion of dibucaine (ear drops) in a 7-year-old child who developed diplopia, giddiness, ventricular premature contractions and a right bundle branch block. We also present a brief discussion on the pharmacologic and toxicity profile of dibucaine, the Naranjo algorithm for assessing causality in case of adverse drug reactions and a review of current guidelines on the management of local anaesthetic systemic toxicity.
- Subjects
LOCAL anesthetics; DRUG side effects; DIBUCAINE; CHILDREN'S health; UNITED States. Food &; Drug Administration
- Publication
Indian Journal of Anaesthesia, 2017, Vol 61, Issue 7, p587
- ISSN
0019-5049
- Publication type
Article
- DOI
10.4103/ija.IJA_166_17