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- Title
Virulence genotypes and drug resistance of Helicobacter pylori from Vladivostok, Russia: another feature in the Far East.
- Authors
Reva, Ivan; Takano, Tomomi; Higuchi, Wataru; Iwao, Yasuhisa; Taneike, Ikue; Nakagawa, Saori; Ike, Masami; Pererva, Oleg; Tarankov, Alexey; Agapov, Mikhail; Rizhkov, Evgeniy; Singur, Olga; Reva, Galina; Potapov, Vladimir; Yamamoto, Tatsuo
- Abstract
ABSTRACT Helicobacter pylori in Vladivostok, Far Eastern Russia, was investigated during 2004 to 2009. The genotype cagA+ vacA+ (s1/m1 or m2) accounted for 74.7%, with cagA− vacA+ (s2/m2) at 11.2%. The CagA EPIYA type was mainly Western ABC, with minor types (ABCCC and novel AAABC) or non-Western/non-East Asia type (AB). Regarding drug resistance, metronidazole resistance was the highest, with a marked decrease in 6 years (from 71.4% to 30.8%); in contrast, levofloxacin and clarithromycin resistance increased. The data indicate that in Vladivostok, H. pylori was mainly the Western (not East Asian) type and dynamic changes in drug resistance occurred during 6 years.
- Subjects
VLADIVOSTOK (Russia); RUSSIA; MICROBIAL virulence; DRUG resistance; HELICOBACTER pylori; METRONIDAZOLE; PATHOGENIC microorganisms
- Publication
Microbiology & Immunology, 2012, Vol 56, Issue 3, p198
- ISSN
0385-5600
- Publication type
Article
- DOI
10.1111/j.1348-0421.2011.00425.x