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- Title
c-kit Expression in small cell carcinoma of the urinary bladder: prognostic and therapeutic implications.
- Authors
Chong-Xian Pan; Yang, Ximing J.; Lopez-Beltran, Antonio; MacLennan, Gregory T.; Eble, John N; Koch, Michael O.; Jones, Timothy D.; Haiqun Lin; Nigro, Kelly; Papavero, Veronica; Tretiakova, Maria; Liang Cheng
- Abstract
The prognosis for small cell carcinoma of the urinary bladder is poor, and strategies for improved therapy are needed. Targeted therapy against the c-kit proto-oncogene has been successful in the management of gastrointestinal stromal tumor. We investigated the expression of c-kit in 52 cases of small cell carcinoma of the urinary bladder. Specimens with more than 10%of cells demonstrating strong membrane staining were considered to have positive immunostaining for c-kit. c-kit expression was detected in 21 of 52 specimens from these patients. Among the 21 specimens, seven had less than 10%staining, and were considered to be negative. Nine had 11-50%staining, and five had more than 50%staining. Overall, 14 of 52 (27%) small cell carcinomas of the urinary bladder were positive for c-kit expression. During a median follow-up of 11 months, 60%of the patients died of bladder cancer. No association was found between c-kit expression and survival or other clinicopathologic parameters. Five-year cancer-specific survivals for c-kit-positive and c-kit-negative tumors were 9 and 15%, respectively (P=0.36). A significant proportion (27%) of small cell carcinomas of the urinary bladder expressed c-kit, suggesting that it may prove useful as a therapeutic target in small cell carcinoma of the urinary bladder.Modern Pathology (2005) 18, 320-323, advance online publication, 15 October 2004; doi:10.1038/modpathol.3800318
- Subjects
CANCER prognosis; URINARY organs; BLADDER; THERAPEUTICS; TUMORS; PREVENTIVE medicine
- Publication
Modern Pathology, 2005, Vol 18, Issue 3, p320
- ISSN
0893-3952
- Publication type
Article
- DOI
10.1038/modpathol.3800318