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- Title
Anti-Histone Acetyltransferase Activity from Allspice Extracts Inhibits Androgen Receptor-Dependent Prostate Cancer Cell Growth.
- Authors
Yoo-hyun Lee; Soon Won Hong; Woojin Jun; Hong Yon Cho; Han-cheon Kim; Myung Gu Jung; Jiemin Wong; Ha-il Kim; Chang-Hoon Kim; Ho-Geun Yoon
- Abstract
The article discusses a study which examines the role of anti-histone acetyltransferase activity from allspice extracts in inhibiting the growth of androgen receptor-dependent prostate cancer cells. Potent histone acetyltransferase inhibitory activity of allspice reduced androgen receptor and histone acetylation, leading to the decrease in transcription of androgen receptor target genes. This resulted to the inhibition of prostate cancer cell growth.
- Subjects
ACETYLTRANSFERASES; ALLSPICE; CANCER cell growth; PROSTATE cancer; PLANT extracts; ANDROGENS; HISTONES; ACETYLATION
- Publication
Bioscience, Biotechnology & Biochemistry, 2007, Vol 71, Issue 11, p2712
- ISSN
0916-8451
- Publication type
Article
- DOI
10.1271/bbb.70306