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- Title
High-grade serous ovarian carcinoma with a sertoliform pattern associated with BRCA mutation: a clinicopathological and molecular analysis.
- Authors
Travaglino, Antonio; Santoro, Angela; Arciuolo, Damiano; Raffone, Antonio; Scaglione, Giulia; D'Alessandris, Nicoletta; Valente, Michele; Sfregola, Stefania; Fulgione, Caterina; Onori, Maria Elisabetta; Minucci, Angelo; Zannoni, Gian Franco
- Abstract
Herein, we report a clinicopathological and molecular analysis of a case of tubo-ovarian high-grade serous carcinoma (HGSC) with a sertoliform pattern. A 45-year-old woman underwent surgery due to an advanced bilateral adnexal carcinoma with peritoneal and appendiceal metastases. Histological examination revealed an HGSC exhibiting a distinct sertoliform component. Such component showed diffuse PAX8, p53 (mutation-type), and p16 (block-type) expression, increased vimentin and decreased WT1 expression compared to the conventional HGSC component, membrane β-catenin positivity, heterogeneous estrogen, and progesterone positivity, and retained PTEN and mismatch repair expression and negativity for GATA3, TTF1, inhibin, calretinin, CD10, CDX2, chromogranin, and synaptophysin. Molecular analysis showed a germline BRCA2 mutation; no mutations were detected in POLE, POLD1, MLH1, MSH2, MSH6, PMS2, APC, CTNNB1, MUTYH, and EPCAM. In conclusion, a sertoliform pattern can be part of the morphological spectrum of BRCA-related HGSC.
- Subjects
BRCA genes; CARCINOMA; CLINICAL pathology; GENETIC mutation; INHIBIN; DNA mismatch repair; P53 antioncogene
- Publication
Virchows Archiv: European Journal of Pathology, 2023, Vol 483, Issue 6, p879
- ISSN
0945-6317
- Publication type
Article
- DOI
10.1007/s00428-023-03556-z