We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Tbx3 overexpression in human gastric cancer is correlated with advanced tumor stage and nodal status and promotes cancer cell growth and invasion.
- Authors
Miao, Zhi-Feng; Liu, Xing-Yu; Xu, Hui-Mian; Wang, Zhen-Ning; Zhao, Ting-Ting; Song, Yong-Xi; Xing, Ya-Nan; Huang, Jin-Yu; Zhang, Jun-Yan; Xu, Hao; Xu, Ying-Ying
- Abstract
The objective of the current study was to investigate the expression pattern of Tbx3 and its clinicopathological significance in patients with gastric cancer. The expression pattern of Tbx3 in gastric cancer tissues and adjacent noncancerous surface epithelia and mucosal glands was detected by immunohistochemistry. Tbx3 was found to be overexpressed in 46 of 98 human gastric cancer samples, and this correlated with advanced clinical stage, tumor stage, and nodal status. In addition, in the SGC-7901 gastric cancer cell line, Tbx3 overexpression by plasmid transfection promoted growth and invasion. Conversely, depleting Tbx3 expression by small-interfering RNA inhibited proliferation and invasion in BGC-823 cell line. Moreover, Tbx3 accelerated cell cycle progression at the G1/S boundary. Tbx3 also regulated epithelial-to-mesenchymal transition (EMT) to promote cell invasion by repressing E-cadherin expression and increasing expression levels N-cadherin, vimentin. These results indicate that in gastric cancer, Tbx3 plays an important role and might be a useful therapy target.
- Subjects
CANCER; IMMUNOHISTOCHEMISTRY; TUMORS; CELL lines; CADHERINS; PROTEIN metabolism; CANCER invasiveness; CELL physiology; CELL motility; GENES; RNA; STOMACH tumors; TUMOR classification; NEOPLASTIC cell transformation; DIAGNOSIS
- Publication
Virchows Archiv: European Journal of Pathology, 2016, Vol 469, Issue 5, p505
- ISSN
0945-6317
- Publication type
journal article
- DOI
10.1007/s00428-016-2007-9