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- Title
Human polyomavirus modulation of the host DNA damage response.
- Authors
Tahseen, Danyal; Rady, Peter L.; Tyring, Stephen K.
- Abstract
The human DNA damage response (DDR) is a complex signaling network constituting many factors responsible for the preservation of genomic integrity. Human polyomaviruses (HPyVs) are able to harness the DDR machinery during their infectious cycle by expressing an array of tumor (T) antigens. These molecular interactions between human polyomavirus T antigens and the DDR create conditions that promote viral replication at the expense of host genomic stability to cause disease as well as carcinogenesis in the cases of the Merkel cell polyomavirus and BK polyomavirus. This review focuses on the six HPyVs with disease association, emphasizing strain-dependent differences in their selective manipulation of the DDR. Appreciation of the HPyV–DDR interface at a molecular scale is conducive to the development of novel therapeutic approaches.
- Subjects
DNA repair; DNA damage; POLYOMAVIRUSES; MERKEL cells; MOLECULAR interactions; VIRAL replication; HUMAN DNA
- Publication
Virus Genes, 2020, Vol 56, Issue 2, p128
- ISSN
0920-8569
- Publication type
Article
- DOI
10.1007/s11262-020-01736-6