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- Title
Intracoronary Monocyte Chemoattractant Protein 1 and Vascular Endothelial Growth Factor Levels Are Associated with Necrotic Core, Calcium and Fibrous Tissue Atherosclerotic Plaque Components: An Intracoronary Ultrasound Radiofrequency Study.
- Authors
Fuchs, Shmuel; Lavi, Ifat; Tzang, Omer; Bessler, Hana; Brosh, David; Bental, Tamir; Dvir, Danny; Einav, Shmuel; Kornowski, Ran
- Abstract
Aims: To investigate the relationship between various serum biomarkers and coronary atherosclerotic plaque composition obtained by intravascular ultrasound virtual histology (IVUS-VH). Methods: Using ELISA, we measured the serum levels of CD40 ligand, C-reactive protein, monocyte chemoattractant protein 1 (MCP-1), metalloproteinase 9, P-selectin and vascular endothelial growth factor (VEGF) in 40 patients with manifested coronary artery disease. Results: Correlation analysis between biomarkers levels, IVUS grayscale parameters and VH-defined necrotic core (NC), calcium, fibrous and fibrofatty components was performed. MCP-1 and VEGF levels correlated with the severity of area stenosis (r = 0.35, p = 0.03 and r = 0.38, p = 0.017, respectively) and inversely correlated with the remodeling index (r = -0.35, p = 0.03 and r = 0.35, p = 0.02, respectively). Higher levels of MCP-1 were associated with increased calcium (r = 0.47, p = 0.004), NC (r = 0.38, p = 0.02) and less fibrous tissue components (r = -0.34, p = 0.03), whereas VEGF had an inverse correlation with both calcium components (r = -0.37, p = 0.02) and NC (r = -0.34, p = 0.036) but was strongly associated with increased fibrous components (r = 0.47, p = 0.003). No significant correlation was noted for any of the other biomarkers. Conclusions: MCP-1 and VEGF serum levels in patients with ischemic heart disease are correlated with coronary artery plaque burden and composition. Copyright © 2012 S. Karger AG, Basel
- Subjects
MONOCYTES; VASCULAR endothelial growth factors; CALCIUM; TISSUES; RADIO frequency; ATHEROSCLEROTIC plaque; CYTOKINES
- Publication
Cardiology, 2012, Vol 123, Issue 2, p125
- ISSN
0008-6312
- Publication type
Article
- DOI
10.1159/000342050