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- Title
Oncogenic osteomalacia illustrating the effect of fibroblast growth factor 23 on phosphate homeostasis.
- Authors
Westerberg, Per-Anton; Linde, Torbjörn; Vanderschueren, Dirk; Billen, Jaak; Jans, Ivo; Ljunggren, Östen
- Abstract
In oncogenic osteomalacia (OOM), fibroblast growth factor 23 (FGF23) induces renal phosphate wasting and inhibits the appropriate increase of calcitriol. A patient suffering from OOM is described. Serum calcium, phosphate, biointact parathyroid hormone and intact FGF23 as well as the calcitriol and 24,25-vitamin D levels were measured before and after tumour removal. The clinical approach to a patient with hypophosphataemia is discussed and the changes in mineral metabolism after removal of a FGF23-producing tumour are described.
- Subjects
OSTEOMALACIA; FIBROBLAST growth factors; CARCINOGENESIS; PHOSPHATES; HOMEOSTASIS; CALCITRIOL; MINERAL metabolism
- Publication
Nephrology Dialysis Transplantation, 2012, Vol 5, Issue 3, p240
- ISSN
0931-0509
- Publication type
Article