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- Title
Expression of sialidase and dystroglycan in human glomerular diseases.
- Authors
Vogtländer, Nils P. J.; Van der Vlag, Johan; Bakker, Marinka A. H.; Dijkman, Henry B.; Wevers, Ron A.; Campbell, Kevin P.; Wetzels, Jack F. M.; Berden, Jo H. M.
- Abstract
Background. α-Dystroglycan (α-DG) is a negatively charged glycoprotein that covers the surface of podocytes. A decreased glomerular expression of α-DG has been described in minimal change nephropathy (MCN), but not in focal segmental glomerulosclerosis (FSGS). This was suggested as a tool to distinguish these diseases. Sialic acid is a negatively charged carbohydrate extensively present on both α-DG and podocalyxin, which is also expressed on podocytes. Intrarenal perfusion with bacterial sialidase leads to foot process effacement and proteinuria. This is the first study on the expression of endogenous glomerular sialidase; furthermore, the expression of dystroglycan was re-evaluated.
- Subjects
NEURAMINIDASE; GLYCOPROTEINS; SIALIC acids; GLYCOSIDASES; KIDNEY diseases
- Publication
Nephrology Dialysis Transplantation, 2010, Vol 25, Issue 2, p478
- ISSN
0931-0509
- Publication type
Article
- DOI
10.1093/ndt/gfp465