We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Physical activity and maintaining of the proteome in the aging process - are these footsteps on the way to longevity?
- Authors
Petrescu, Bogdan Mircea; Riga, Sorin; Vasiliu, Octavian; Mangalagiu, Andrei Gabriel
- Abstract
Accumulation of dysfunctional and damaged cellular proteins and organelles occurs during aging, resulting in a perturbation of cell homeostasis and inexorable degeneration up to cellular death. Therefore, moderating these components may be a key in the promotion of longevity. Exercise is known to promote healthy aging and mitigate age-related pathologies, and recent studies suggest that exercise modulates the proteome. Autophagy is an evolutionary conserved recycling pathway managing degradation, and it declines during aging. The target of rapamycin complex 1 (TORC1), a central kinase involved in protein translation, is a negative regulator of autophagy, and inhibition of TORC1 enhances lifespan. As a consequence, the longevity effects of exercise may stem from the maintenance of the proteome by balancing the synthesis and recycling of intracellular proteins, and thus may promote longevity.Participation in vigorous physical activity at a specific time point is an indicator of good fitness and health and is associated with a reduced risk of death. However, randomized controlled trials (RCTs) and translational models have not provided strong evidence to show that physical activity started during adulthood extends lifespan and promotes longevity. Physical activity improves fitness and physical function, and confers other health-related effects.
- Subjects
PROTEOMICS; PHYSICAL activity; PHYSIOLOGICAL aspects of aging
- Publication
Health, Sports & Rehabilitation Medicine, 2021, Vol 22, Issue 2, p120
- ISSN
2668-2303
- Publication type
Article
- DOI
10.26659/pm3.2021.22.2.120