We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Serotonin Syndrome in an Infant Associated With Linezolid and Opioid Use.
- Authors
Essakow, Jenna; Jin, Lulu; Marupudi, Neelima; Wattier, Rachel; McQuillen, Patrick; Franzon, Deborah
- Abstract
Most reported cases of serotonin syndrome involve either a selective serotonin reuptake inhibitor (SSRI) or monoamine oxidase inhibitors (MAOI) and at least 1 other serotonergic medication or exposure to a single serotonin-augmenting drug. This case report describes serotonin syndrome occurring in association with the concomitant use of the antibiotic linezolid and opioids, specifically methadone, in a pediatric intensive care unit patient. The patient developed hyperpyrexia, muscle rigidity, clonus, and multiorgan dysfunction within 48 hours of receiving linezolid while concurrently on methadone. This drug-drug interaction is a rare cause of serotonin syndrome that has only been described 1 other time in the adult literature. This report raises awareness of this rare but serious and potentially lethal complication of serotonin syndrome associated with concomitant linezolid and opioid use. Timely consideration of the diagnosis in the setting of hyperpyrexia can facilitate prompt initiation of targeted therapies to prevent sequela.
- Subjects
LINEZOLID; SEROTONIN syndrome; SEROTONIN; SEROTONIN uptake inhibitors; INTENSIVE care patients; MONOAMINE oxidase inhibitors; PEDIATRIC intensive care
- Publication
Journal of Pediatric Pharmacology & Therapeutics, 2022, Vol 27, Issue 6, p564
- ISSN
1551-6776
- Publication type
Article
- DOI
10.5863/1551-6776-27.6.564