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- Title
The effect of weight loss on changes in health-related quality of life among overweight and obese women with urinary incontinence.
- Authors
Pinto, Angela; Subak, Leslee; Nakagawa, Sanae; Vittinghoff, Eric; Wing, Rena; Kusek, John; Herman, William; West, Delia; Kuppermann, Miriam
- Abstract
Objective: To estimate the effect of change in weight and change in urinary incontinence (UI) frequency on changes in preference-based measures of health-related quality of life (HRQL) among overweight and obese women with UI participating in a weight loss trial. Methods: We conducted a longitudinal cohort analysis of 338 overweight and obese women with UI enrolled in a randomized clinical trial comparing a behavioral weight loss intervention to an educational control condition. At baseline, 6, and 18 months, health utilities were estimated using the Health Utilities Index Mark 3 (HUI3), a transformation of the SF-36 to the preference-based SF-6D, and the estimated Quality of Well-Being (eQWB) score (a summary calculated from the SF-36 physical functioning, mental health, bodily pain, general health perceptions, and role limitations-physical subscale scores). Potential predictors of changes in these outcomes were examined using generalized estimating equations. Results: In adjusted multivariable models, weight loss was associated with improvement in HUI3, SF-6D, and eQWB at 6 and 18 months ( P < 0.05). Increases in physical activity also were independently associated with improvement in HUI3 ( P = 0.01) and SF-6D ( P = 0.006) scores at 18 months. In contrast, reduction in UI frequency did not predict improvements in HRQL at 6 or 18 months. Conclusion: Weight loss and increased physical activity, but not reduction in UI frequency, were strongly associated with improvements in health utilities measured by the HUI3, SF-6D, and eQWB. These findings provide important information that can be used to inform cost-utility analyses of weight loss interventions.
- Subjects
DISEASES in women; WEIGHT loss; OBESITY in women; QUALITY of life; URINARY incontinence; ESTIMATION theory; COHORT analysis; CLINICAL trials
- Publication
Quality of Life Research, 2012, Vol 21, Issue 10, p1685
- ISSN
0962-9343
- Publication type
Article
- DOI
10.1007/s11136-011-0086-2