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- Title
Platelet-derived growth factor (PDGF) receptors in the developing mouse optic pathway.
- Authors
Hutchins, James B.; Zhang, Xiaorong
- Abstract
The molecules which control the patterns of cell division, growth, and precise interconnections characteristic of the central nervous system still remain largely unidentified. The protein platelet-derived growth factor (PDGF) has been shown to mediate interactions among glial cells in vitro. More recent evidence has indicated that PDGF may also be involved in controlling communication between neurons and glial cells and among neurons. The presence of receptors for PDGF on neurons of the developing nervous system is an essential piece of evidence in this chain of events. Ganglion cells are labeled with antibodies to PDGF receptor only during the period of active process outgrowth. These findings suggest that PDGF is used as a mediator of intercellular signaling during neuronal development.
- Publication
Visual Neuroscience, 1994, Vol 11, Issue 1, p33
- ISSN
0952-5238
- Publication type
Article
- DOI
10.1017/S0952523800011081