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- Title
Fine-mapping cis-regulatory variants in diverse human populations.
- Authors
Tehranchi, Ashley; Hie, Brian; Dacre, Michael; Kaplow, Irene; Pettie, Kade; Combs, Peter; Fraser, Hunter B.
- Abstract
Genome-wide association studies (GWAS) are a powerful approach for connecting genotype to phenotype. Most GWAS hits are located in cis-regulatory regions, but the underlying causal variants and their molecular mechanisms remain unknown. To better understand human cisregulatory variation, we mapped quantitative trait loci for chromatin accessibility (caQTLs)—a key step in cis-regulation—in 1000 individuals from 10 diverse populations. Most caQTLs were shared across populations, allowing us to leverage the genetic diversity to fine-map candidate causal regulatory variants, several thousand of which have been previously implicated in GWAS. In addition, many caQTLs that affect the expression of distal genes also alter the landscape of longrange chromosomal interactions, suggesting a mechanism for long-range expression QTLs. In sum, our results show that molecular QTL mapping integrated across diverse populations provides a high-resolution view of how worldwide human genetic variation affects chromatin accessibility, gene expression, and phenotype.
- Publication
eLife, 2019, p1
- ISSN
2050-084X
- Publication type
Article
- DOI
10.7554/eLife.39595.001