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- Title
Development of a new risk stratification system for patients with newly diagnosed multiple myeloma using R-ISS and <sup>18</sup>F-FDG PET/CT.
- Authors
Cho, Hee Jeong; Jung, Sung-Hoon; Jo, Jae-Cheol; Lee, Yoo Jin; Yoon, Sang Eun; Park, Sung-Soo; Kim, Do Young; Shin, Ho-Jin; Mun, Yeung-Chul; Yi, Jun Ho; Kim, Hyo Jung; Kim, Da Jung; Lee, Ho Sup; Bae, Sung Hwa; Hong, Chae Moon; Jeong, Shin Young; Min, Jung-Joon; Sohn, Sang Kyun; Min, Chang-Ki; Kim, Kihyun
- Abstract
In multiple myeloma (MM), a high number of focal lesions (FL) detected using positron emission tomography/computed tomography (PET/CT) was found to be associated with adverse prognosis. To design a new risk stratification system that combines the Revised International Staging System (R-ISS) with FL, we analyzed the data of 380 patients with newly diagnosed MM (NDMM) who underwent 18F-fluorodeoxyglucose (18F-FDG) PET/CT upon diagnosis. The K-adaptive partitioning algorithm was adopted to define subgroups with homogeneous survival. The combined R-ISS with PET/CT classified NDMM patients into four groups: R-ISS/PET stage I (n = 31; R-ISS I with FL ≤ 3), stage II (n = 156; R-ISS I with FL > 3 and R-ISS II with FL ≤ 3), stage III (n = 162; R-ISS II with FL > 3 and R-ISS III with FL ≤ 3), and stage IV (n = 31; R-ISS III with FL > 3). The 2-year overall survival rates for stages I, II, III, and IV were 96.7%, 89.8%, 74.7%, and 50.3%. The 2-year progression-free survival rates were 84.1%, 64.7%, 40.8%, and 17.1%, respectively. The new R-ISS/PET was successfully validated in an external cohort. This new system had a remarkable prognostic power for estimating the survival outcomes of patients with NDMM. This system helps discriminate patients with a good prognosis from those with a poor prognosis more precisely.
- Subjects
MULTIPLE myeloma; POSITRON emission tomography computed tomography; PROGRESSION-free survival; SURVIVAL rate; OVERALL survival
- Publication
Blood Cancer Journal, 2021, Vol 11, Issue 12, p1
- ISSN
2044-5385
- Publication type
Article
- DOI
10.1038/s41408-021-00577-2