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- Title
Integrative multi‐omics approach for mechanism of humidifier disinfectant‐associated lung injury.
- Authors
Kim, Jeong‐Hyun; Kim, Kwoneel; Yeom, Jeonghun; Lee, Eun; Kang, Mi‐Jin; Lee, Seung‐Hwa; Kim, Kyunggon; Lee, So‐Yeon; Hong, Sang‐Bum; Oh, Dong Kyu; Lee, Kyuhong; Choi, Seong‐Jin; Yang, Mi‐Jin; Kim, Jiyeon; Hong, Soo‐Jong
- Abstract
(C) Genes overlapping between human lung tissues with HDLI and rat lung tissues exposed to PHMG. In the ingenuity pathway analysis (IPA), significant networks, canonical pathway, and disease/bio-function were predicted in human lung tissues with HDLI and rat lung tissues exposed to PHMG (Tables S7-S9). GLO:F2H7/01nov21:ctm2562-fig-0001.jpg PHOTO (COLOR): 1 Transcriptome and proteome analyses of human lung tissues from patients with HDLI and rat lung tissues from animals exposed to PHMG. Dear Editor, Inhalational exposure to toxic chemicals present in humidifier disinfectant (HD), such as polyhexamethylene guanidine (PHMG), was identified as a cause of the serious lung injury,1-3 and this fatal humidifier disinfectant-associated lung injury (HDLI), as characterized by rapid progression of respiratory failure with lung fibrosis and frequent air leak syndrome with high mortality, was classified as a subcategory of interstitial lung diseases (ILDs).4,5 However, differences in clinical progression, high mortality (44-58%), and pathology between HDLI and previously identified ILDs have aroused interest over the mechanisms of these serious lung diseases.1,2,6 The aim of the present study was to explore regulatory molecules and gain insight into the comprehensive biological processes associated with HDLI using integrated multispecies multi-omics of human and rat lung tissues exposed to PHMG.
- Subjects
LUNG injuries; HUMIDIFIERS; LUNGS; CELLULAR signal transduction; ORAL submucous fibrosis; PROTEOMICS; FIBROBLASTS
- Publication
Clinical & Translational Medicine, 2021, Vol 11, Issue 11, p1
- ISSN
2001-1326
- Publication type
Article
- DOI
10.1002/ctm2.562