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- Title
Expression of COX-2 is increased with age in papillary thyroid cancer.
- Authors
Siironen, P.; Ristimäki, A.; Nordling, S.; Louhimo, J.; Haapiainen, R.; Haglund, C.
- Abstract
To study cyclooxygenase-2 (COX-2) and matrix metalloproteinase-2 (MMP-2) expression in papillary thyroid cancer (PTC). Expression of COX-2 is elevated in various human tumours and it has an important role in carcinogenesis. MMP-2 is also an important component of the metastatic potential of tumours. In PTC the most important factor affecting survival is age, but it is poorly understood why older PTC patients have a worse prognosis. Our study shows that COX-2 expression increases with age. It is possible that the age-related increase in COX-2 expression could explain the more aggressive behaviour of PTC in the older age group compared with the young one.
- Subjects
CYCLOOXYGENASE 2; METALLOPROTEINASES; THYROID cancer; CARCINOGENESIS; METASTASIS; IMMUNOHISTOCHEMISTRY
- Publication
Histopathology, 2004, Vol 44, Issue 5, p490
- ISSN
0309-0167
- Publication type
Article
- DOI
10.1111/j.1365-2559.2004.01880