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- Title
Prospective associations between a priori dietary patterns adherence and kidney function in an elderly Mediterranean population at high cardiovascular risk.
- Authors
Valle-Hita, Cristina; Díaz-López, Andrés; Becerra-Tomás, Nerea; Martínez-González, Miguel A.; García, Verónica Ruiz; Corella, Dolores; Goday, Albert; Martínez, J. Alfredo; Alonso-Gómez, Ángel M.; Wärnberg, Julia; Vioque, Jesús; Romaguera, Dora; López-Miranda, José; Estruch, Ramon; Tinahones, Francisco J.; Lapetra, José; Serra-Majem, Luís; Cano-Ibáñez, Naomi; Tur, Josep A.; Rubín-García, María
- Abstract
Purpose: To assess the association between three different a priori dietary patterns adherence (17-item energy reduced-Mediterranean Diet (MedDiet), Trichopoulou-MedDiet and Dietary Approach to Stop Hypertension (DASH)), as well as the Protein Diet Score and kidney function decline after one year of follow-up in elderly individuals with overweight/obesity and metabolic syndrome (MetS). Methods: We prospectively analyzed 5675 participants (55–75 years) from the PREDIMED-Plus study. At baseline and at one year, we evaluated the creatinine-based estimated glomerular filtration rate (eGFR) and food-frequency questionnaires-derived dietary scores. Associations between four categories (decrease/maintenance and tertiles of increase) of each dietary pattern and changes in eGFR (ml/min/1.73m2) or ≥ 10% eGFR decline were assessed by fitting multivariable linear or logistic regression models, as appropriate. Results: Participants in the highest tertile of increase in 17-item erMedDiet Score showed higher upward changes in eGFR (β: 1.87 ml/min/1.73m2; 95% CI: 1.00–2.73) and had lower odds of ≥ 10% eGFR decline (OR: 0.62; 95% CI: 0.47–0.82) compared to individuals in the decrease/maintenance category, while Trichopoulou-MedDiet and DASH Scores were not associated with any renal outcomes. Those in the highest tertile of increase in Protein Diet Score had greater downward changes in eGFR (β: − 0.87 ml/min/1.73m2; 95% CI: − 1.73 to − 0.01) and 32% higher odds of eGFR decline (OR: 1.32; 95% CI: 1.00–1.75). Conclusions: Among elderly individuals with overweight/obesity and MetS, only higher upward change in the 17-item erMedDiet score adherence was associated with better kidney function after one year. However, increasing Protein Diet Score appeared to have an adverse impact on kidney health. Trial Registration Number: ISRCTN89898870 (Data of registration: 2014).
- Subjects
MEDITERRANEAN Region; KIDNEY physiology; HEART disease risk factors; CARDIOVASCULAR diseases risk factors; MEDITERRANEAN diet; HYPERTENSION; OBESITY; MEDITERRANEAN peoples; CONFIDENCE intervals; DIET; METABOLIC syndrome; PATIENT compliance; ODDS ratio; LONGITUDINAL method; OLD age
- Publication
European Journal of Nutrition, 2022, Vol 61, Issue 6, p3095
- ISSN
1436-6207
- Publication type
Article
- DOI
10.1007/s00394-022-02838-7