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- Title
Meroterpenoids from Marine Sponge Hyrtios sp. and Their Anticancer Activity against Human Colorectal Cancer Cells.
- Authors
Wang, Jie; Yan, Yue-Lu; Yu, Xin-Yi; Pan, Jia-Yan; Liu, Xin-Lian; Hong, Li-Li; Wang, Bin
- Abstract
Two new meroterpenoids, hyrtamide A (1) and hyrfarnediol A (2), along with two known ones, 3-farnesyl-4-hydroxybenzoic acid methyl ester (3) and dictyoceratin C (4), were isolated from a South China Sea sponge Hyrtios sp. Their structures were elucidated by NMR and MS data. Compounds 2–4 exhibited weak cytotoxicity against human colorectal cancer cells (HCT-116), showing IC50 values of 41.6, 45.0, and 37.3 μM, respectively. Furthermore, compounds 3 and 4 significantly suppressed the invasion of HCT-116 cells while also downregulating the expression of vascular endothelial growth factor receptor 1 (VEGFR-1) and vimentin proteins, which are key markers associated with angiogenesis and epithelial–mesenchymal transition (EMT). Our findings suggest that compounds 3 and 4 may exert their anti-invasive effects on tumor cells by inhibiting the expression of VEGFR-1 and impeding the process of EMT.
- Subjects
VASCULAR endothelial growth factor receptors; COLORECTAL cancer; SPONGES (Invertebrates); CANCER cells; ANTINEOPLASTIC agents
- Publication
Marine Drugs, 2024, Vol 22, Issue 4, p183
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md22040183