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- Title
Applications of Mitomycin C in Cornea and External Disease.
- Authors
Crespo, Marcos A.; Rapuano, Christopher J.; Syed, Zeba A.
- Abstract
Isolated from Streptomyces caespitosus, mitomycin C (MMC) has various applications in the management of corneal and external disease due to its ability to modulate cellular proliferation. It has been employed in pterygium surgery, ocular surface neoplasia, and refractive surgery. Currently, there is no definite consensus on the treatment protocols for each of the aforementioned applications. Although its benefits in the management of corneal and external diseases are promising, MMC use has potential complications including endothelial cell loss, corneal perforation, scleral melt, secondary glaucoma, iritis, and endophthalmitis. This article will review the literature regarding the use of MMC in the field of cornea and external disease and describe protocols employed with corresponding outcomes.
- Subjects
ENDOTHELIAL cells; MITOMYCINS; GLAUCOMA; CORNEA diseases; OCULAR tumors; MEDICAL protocols; TREATMENT effectiveness; PTERYGIUM; IRITIS; CELL proliferation; ENDOPHTHALMITIS; GRAM-positive bacteria; PHOTOREFRACTIVE keratectomy
- Publication
Turkish Journal of Ophthalmology / Turk Oftalmoloji Dergisi, 2023, Vol 53, Issue 3, p175
- ISSN
1300-0659
- Publication type
Article
- DOI
10.4274/tjo.galenos.2023.97932