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- Title
A Cytotoxic Porphyrin from North Pacific Brittle Star Ophiura sarsii.
- Authors
Klimenko, Antonina; Huber, Robin; Marcourt, Laurence; Chardonnens, Estelle; Koval, Alexey; Khotimchenko, Yuri S.; Ferreira Queiroz, Emerson; Wolfender, Jean-Luc; Katanaev, Vladimir L.
- Abstract
Triple-negative breast cancer (TNBC) represents the deadliest form of gynecological tumors currently lacking targeted therapies. The ethanol extract of the North Pacific brittle star Ophiura sarsii presented promising anti-TNBC activities. After elimination of the inert material, the active extract was submitted to a bioguided isolation approach using high-resolution semipreparative HPLC-UV, resulting in one-step isolation of an unusual porphyrin derivative possessing strong cytotoxic activity. HRMS and 2D NMR resulted in the structure elucidation of the compound as (3S,4S)-14-Ethyl-9-(hydroxymethyl)-4,8,13,18-tetramethyl-20-oxo-3-phorbinepropanoic acid. Never identified before in Ophiuroidea, porphyrins have found broad applications as photosensitizers in the anticancer photodynamic therapy. The simple isolation of a cytotoxic porphyrin from an abundant brittle star species we describe here may pave the way for novel natural-based developments of targeted anti-cancer therapies.
- Subjects
PORPHYRINS; TRIPLE-negative breast cancer; PHOTODYNAMIC therapy
- Publication
Marine Drugs, 2021, Vol 19, Issue 1, p11
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md19010011