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- Title
Parity as a Prognostic Factor in Patients with Advanced-Stage Epithelial Ovarian Cancer.
- Authors
Khalafi-Nezhad, Abolfazl; Ebrahimi, Vahid; Ahmadpour, Fatemeh; Momtahan, Mozhdeh; Robati, Minoo; Saraf, Zahra; Ramzi, Mani; Jowkar, Zahra; Ghaffari, Parvin
- Abstract
Aim: This study aimed to determine the prognostic factors influencing the overall survival (OS) of Iranian women with epithelial ovarian cancer (EOC). Methods: Information about newly diagnosed patients with confirmed EOC at Motahari Clinic, Shiraz, Iran, from January 1, 2001, to December 31, 2016, was retrospectively reviewed and analyzed. Cox-adjusted proportional hazards (PH) and stratified Cox (SC) models were used to determine the potential prognostic factors. Results: The mean (±SD) age at the diagnosis of 385 patients with EOC was 49.0 (± 13.2) years old. Early-stage EOC (ESEOC) and advanced-stage EOC (ASEOC) were diagnosed in 34.3% and 65.7% of the total patients, respectively. The median (95% CI) OS was 35 (28− 41) months. For ESEOC patients, a stage II-tumor led to a lower OS in the multivariable analysis compared to a lower stage tumor (P= 0.025). For ASEOC patients, age≥ 65 years at diagnosis (P=0.008) led to a lower OS. ASEOC patients with 2– 5 parities (P=0.014) and > 5 parity (P=0.001) demonstrated better OS than nulliparous women. Conclusion: Patients with ESEOC, higher tumor stage was associated with a shorter OS. The age at diagnosis harmed the OS of patients with ASEOC. More than one parity improved OS in ASEOC patients.
- Subjects
SHIRAZ (Iran); OVARIAN epithelial cancer; TUMOR classification
- Publication
Cancer Management & Research, 2020, Vol 12, p1447
- ISSN
1179-1322
- Publication type
Article
- DOI
10.2147/CMAR.S237073