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- Title
Molecular Functionalization of Planar Nanocrystalline and Porous Nanostructured Diamond to Form an Interface with Newborn and Adult Neurons.
- Authors
Krůšek, Jan; Dittert, Ivan; Smejkalová, Tereza; Kořínek, Miloslav; Gottfriedová, Kristýna; Freislebenová, Hana; Neuhöferová, Eva; Klimša, Ladislav; Sedláková, Silvia; Taylor, Andrew; Mortet, Vincent; Petrák, Václav; Benson, Veronika; Petráková, Vladimíra
- Abstract
This article examines the ability of newly developed nanostructured porous boron‐doped diamond (BDD) to form an interface with neural cells and the role of molecular functionalization by a polymer on this interface. Due to its high stability, biocompatibility, and electrical properties, BDD is a promising material for construction of neuroelectrodes. Nanostructuring and an increase in the surface specific area can further improve the sensitivity and performance of such electrodes. Here, porous BDD prepared in a multistep diamond deposition on a porous template consisting of a polymer and electrospun SiO2 fibers is examined. This work shows that this new material is biocompatible and does not exhibit any cytotoxicity on fibroblast cell lines. Further, this work shows that porous BDD supports regeneration of newborn and adult neurons when functionalized with poly‐L‐lysine. Nanostructured porous boron‐doped diamond is a material suitable for interfacing neonatal and adult neurons when treated with poly‐L‐lysine. Cultivated neurons exhibit normal electrical activity and react to chemically induced excitation or inhibition. Increased surface area of boron‐doped diamond may lead to enhanced performance of all diamond neuroelectrodes.
- Subjects
NANOCRYSTALS; POROUS materials; NANOELECTROMECHANICAL systems; INTERFACES (Physical sciences); BORON
- Publication
Physica Status Solidi (B), 2019, Vol 256, Issue 3, pN.PAG
- ISSN
0370-1972
- Publication type
Article
- DOI
10.1002/pssb.201800424