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- Title
Multiple viral coinfections among HIV/AIDS patients in China.
- Authors
Na He; Li Chen; Haijiang Lin; Man Zhang; Jun Wei; Jianhua Yang; Gabrio, Jenna; Baoling Rui; Zuo-Feng Zhang; Zhuohua Fu; Yingying Ding; Genming Zhao; Qingwu Jiang; Detels, Roger
- Abstract
A cross-sectional survey was conducted to determine seroprevalence and correlates of coinfections of hepatitis B virus (HBV), hepatitis C virus (HCV), Epstein-Bar virus (EBV), herpes simplex virus including type 1 (HSV-1) and type 2 (HSV-2) among human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) patients in China. A total of 1,110 HIV/AIDS patients from Shanxi (Central area, n = 287), Zhejiang (Eastern area, n = 163), Yunnan (Southwestern area, n = 300) and Xinjiang (Northwestern area, n = 360) provinces were analyzed. The overall seroprevalence was 6.3% for HBsAg, 59.0% for anti-HCV IgG, 96.6% for anti-EBV IgG, 91.5% for anti-HSV-1 IgG, and 34.1% for anti-HSV-2 IgG. Eleven (1.0%) HIV/AIDS patients were coinfected with all five viruses, 177 (15.9%) with four viruses, 611 (55.0%) with three viruses, 288 (25.9%) with two viruses, 23 (2.1%) with single virus, and 1 (0.1%) with none of the five viruses. Multiple logistic regression analyses indicated that neither HBV, nor EBV and HSV-1 coinfection was associated with sociodemographic characteristics and HIV transmission mode, but HCV coinfection was associated with geographic region, age, gender, ethnicity, marital status, and HIV transmission mode, whereas HSV-2 coinfection was associated with geographic region, ethnicity and HIV transmission mode. This study suggests that HIV/AIDS patients with different regional and sociodemographic backgrounds and HIV transmission mode in China have different profiles of viral coinfections and should be subject to differential considerations in related health care programs.
- Subjects
CHINA; HEPATITIS B virus; HEPATITIS C virus; HIV-positive persons; AIDS patients; LOGISTIC regression analysis
- Publication
BioScience Trends, 2011, Vol 5, Issue 1, p1
- ISSN
1881-7815
- Publication type
Article
- DOI
10.5582/bst.2011.v5.1.1