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- Title
Emerging Paradigm of Primary Immunodeficiency Disease: Individualizing Immunoglobulin Dose and Delivery to Enhance Outcomes.
- Authors
Shapiro, Ralph; Wasserman, Richard; Bonagura, Vincent; Gupta, Sudhir
- Abstract
An emerging paradigm for the treatment of primary immunodeficiency disease (PIDD) with immunoglobulin (IgG) replacement therapy emphasizes the tailoring of treatments to each patient with the goal of preventing infections and minimizing side effects. Increasing evidence shows that the IgG dose needed to prevent infection varies with each patient, and both intravenous immunoglobulin (IGIV) and subcutaneous immunoglobulin (IGSC) have emerged as feasible modes of delivery. Although IGIV is currently the routine treatment, IGSC is increasingly being chosen as the preferred route of delivery due to greater flexibility and reduced side effects.
- Subjects
IMMUNODEFICIENCY; THERAPEUTIC use of immunoglobulins; DRUG dosage; DRUG delivery systems; INTRAVENOUS immunoglobulins; THERAPEUTICS
- Publication
Journal of Clinical Immunology, 2017, Vol 37, Issue 2, p190
- ISSN
0271-9142
- Publication type
Article
- DOI
10.1007/s10875-014-9990-x