We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Deciphering the Interacting Mechanisms of Circadian Disruption and Alzheimer's Disease.
- Authors
Uddin, Md. Sahab; Sumsuzzman, Dewan Md.; Jeandet, Philippe; Behl, Tapan; Rauf, Abdur; Amran, Md. Shah; Ashraf, Ghulam Md
- Abstract
Alzheimer's disease (AD) is one of the crucial causative factors for progressive dementia. Neuropathologically, AD is characterized by the extracellular accumulation of amyloid beta plaques and intracellular neurofibrillary tangles in cortical and limbic regions of the human brain. The circadian system is one of the many affected physiological processes in AD, the dysfunction of which may reflect in the irregularity of the sleep/wake cycle. The interplay of circadian and sleep disturbances inducing AD progression is bidirectional. Sleep-associated pathological alterations are frequently evident in AD. Understanding the interrelation between circadian disruption and AD may allow for earlier identification of AD pathogenesis as well as better suited approaches and potential therapies to combat dementia. In this article, we examine the existing literature related to the molecular mechanisms of the circadian clock and interacting mechanisms of circadian disruption and AD pathogenesis.
- Subjects
ALZHEIMER'S disease; SUPRACHIASMATIC nucleus; NEUROFIBRILLARY tangles; CIRCADIAN rhythms; AMYLOID plaque; DEMENTIA
- Publication
Neurochemical Research, 2021, Vol 46, Issue 7, p1603
- ISSN
0364-3190
- Publication type
Article
- DOI
10.1007/s11064-021-03325-x