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- Title
Thoracic aortitis and aortic dissection following pegfilgrastim administration.
- Authors
Yuki Sato; Shuichiro Kaji; Hiroyuki Ueda; Keisuke Tomii
- Abstract
The patient was a 67-year-old woman with a history of advanced lung adenocarcinoma. Eight days after pegfilgrastim administration, her computed tomography scan revealed thickened bilateral common carotid arteries and thoracic aorta, which led to the diagnosis of pegfilgrastim-associated aortitis. Thirty-six days after pegfilgrastim administration, asymptomatic Stanford type B aortic dissection was detected. Her serum biomarker analysis suggested that interleukin-6 might be involved in the pathogenesis. Physicians should be aware of these adverse effects of filgrastim.
- Subjects
THORACIC aorta; AORTIC dissection; AORTIC aneurysms; ADENOCARCINOMA; INTERLEUKIN-6; FILGRASTIM; SURGERY
- Publication
European Journal of Cardio-Thoracic Surgery, 2017, Vol 52, Issue 5, p993
- ISSN
1010-7940
- Publication type
Article
- DOI
10.1093/ejcts/ezx165