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- Title
STUDIES ON THE MECHANISM OF THE ANTI-MELANOMA EFFECT OF POLYINOSINIC-POLYCYTIDYLIC ACID (PIC) II. DECREASED GROWTH OF B-16 MELANOMA FROM PRIOR EXPOSURE TO THE TUMOR. ABROGATION OF THIS RESPONSE BY PIC.
- Authors
Bart, Robert S.; Kopf, Alfred W.; Lam, Steven
- Abstract
Prior exposure of C-57 black mice to B-16 malignant melanoma inhibits the growth of subsequent B-16 melanoma implants. Presumably this inhibition is based on an immunologic mechanism. Polyinosinic-polycytidylic acid (PIC), given during the immunization period, abrogated the anti-tumor response. The experiments failed to support the hypothesis that the anti-melanoma effect of PIC is mediated by an immune response.
- Subjects
MELANOMA; NEUROENDOCRINE tumors; IMMUNIZATION; IMMUNITY; TUMORS; PATHOLOGY
- Publication
Journal of Investigative Dermatology, 1972, Vol 59, Issue 6, p442
- ISSN
0022-202X
- Publication type
Article
- DOI
10.1111/1523-1747.ep12627606