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- Title
Risk factors for high cerebral blood flow velocity and death in Kenyan children with Sickle Cell Anaemia: role of haemoglobin oxygen saturation and febrile illness.
- Authors
Makani, Julie; Kirkham, Fenella J.; Komba, Albert; Ajala-Agbo, Tolulope; Otieno, Godfrey; Fegan, Gregory; Williams, Thomas N.; Marsh, Kevin; Newton, Charles R.
- Abstract
High cerebral blood flow velocity (CBFv) and low haemoglobin oxygen saturation (SpO2) predict neurological complications in sickle cell anaemia (SCA) but any association is unclear. In a cross-sectional study of 105 Kenyan children, mean CBFv was 120 ± 34·9 cm/s; 3 had conditional CBFv (170–199 cm/s) but none had abnormal CBFv (>200 cm/s). After adjustment for age and haematocrit, CBFv ≥150 cm/s was predicted by SpO2 ≤ 95% and history of fever. Four years later, 10 children were lost to follow-up, none had suffered neurological events and 11/95 (12%) had died, predicted by history of fever but not low SpO2. Natural history of SCA in Africa may be different from North America and Europe.
- Subjects
KENYA; SICKLE cell anemia in children; TRANSCRANIAL Doppler ultrasonography; CEREBROVASCULAR disease in children; CEREBRAL circulation; DISEASE risk factors
- Publication
British Journal of Haematology, 2009, Vol 145, Issue 4, p529
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/j.1365-2141.2009.07660.x