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- Title
Molecular-genetic insights in paediatric T-cell acute lymphoblastic leukaemia.
- Authors
Van Vlierberghe, Pieter; Pieters, Rob; Beverloo, H. Berna; Meijerink, Jules P. P.
- Abstract
Paediatric T-cell acute lymphoblastic leukaemia (T-ALL) is an aggressive malignancy of thymocytes that accounts for about 15% of ALL cases and for which treatment outcome remains inferior compared to B-lineage acute leukaemias. In T-ALL, leukemic transformation of maturating thymocytes is caused by a multistep pathogenesis involving numerous genetic abnormalities that drive normal T-cells into uncontrolled cell growth and clonal expansion. This review provides an overview of the current knowledge on onco- and tumor suppressor genes in T-ALL and suggests a classification of these genetic defects into type A and type B abnormalities. Type A abnormalities may delineate distinct molecular-cytogenetic T-ALL subgroups, whereas type B abnormalities are found in all major T-ALL subgroups and synergize with these type A mutations during T-cell pathogenesis.
- Subjects
LYMPHOBLASTIC leukemia in children; MOLECULAR genetics; T cells; GENETIC disorders; CLONING
- Publication
British Journal of Haematology, 2008, Vol 143, Issue 2, p153
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/j.1365-2141.2008.07314.x