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- Title
PRV-1, erythroid colonies and platelet Mpl are unrelated to thrombosis in essential thrombocythaemia.
- Authors
Vannucch, Alessandro M.; Grossi, Alberto; Pancrazzi, Alessandro; Antonioli, Elisabetta; Guglielmelli, Paola; Balestri, Francesca; Biscardi, Monica; Bulgarelli, Simona; Longo, Giovanni; Graziano, Claudio; Gugliotta, Luigi; Bosi, Alberto
- Abstract
Females with the monoclonal type of essential thrombocythaemia (ET), based on the X-chromosome inactivation pattern (XCIP), have previously been shown to present a higher incidence of thrombosis than polyclonal ones. We aimed to assess correlations between XCIP, thrombosis, and three epigenetic markers of ET, namelyPRV-1overexpression, endogenous erythroid colony (EEC) formation, and reduced platelet Mpl content. Fifty-three (60%) of 88 subjects studied had monoclonal myelopoiesis and presented a 32% incidence of major thrombosis compared with 6% of polyclonal subjects (P = 0·009). The frequency of abnormalities ofPRV-1, EEC, or Mpl was similar in monoclonal and polyclonal subjects (respectively, 28%, 48%, 75%, and 37%, 27%, 63%), and none of them correlated with thrombosis. We conclude that the exploited epigenetic markers constitute independent phenotypic variations and are not clustered according to monoclonality of myelopoiesis in ET; none of them could serve as a surrogate marker of thrombotic risk in male subjects with ET.
- Subjects
THROMBOSIS; THROMBOCYTOPENIA; CARDIOVASCULAR diseases; BLOOD platelets; X chromosome; SEX chromosomes
- Publication
British Journal of Haematology, 2004, Vol 127, Issue 2, p214
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/j.1365-2141.2004.05175.x