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- Title
Clearance of coagulation factor VIII in very low-density lipoprotein receptor knockout mice.
- Authors
Bovenschen, Niels; van Dijk, Ko Willems; Havekes, Louis M.; Mertens, Koen; van Vlijmen, Bart J. M.
- Abstract
Low-density lipoprotein receptor-related protein (LRP) contributes to factor VIII (FVIII) catabolism in vivo. Besides LRP, FVIII also interacts with very low-density lipoprotein receptor (VLDLR) in vitro. We investigated the physiological role of VLDLR in FVIII catabolism, using knockout mouse models for VLDLR and LRP, alone and in combination. VLDLR−/− mice displayed normal plasma FVIII, whereas VLDLR−/− LRP− double-knockout mice had slightly increased FVIII compared with LRP-deficient mice. Remarkably, VLDLR deficiency slightly accelerated FVIII clearance. Adenovirus-mediated overexpression of VLDLR did not lower plasma FVIII in LRP-deficient mice. We conclude that VLDLR does not act in concert with LRP in FVIII clearance in vivo.
- Subjects
BLOOD coagulation; LIPOPROTEINS; METABOLISM; BLOOD plasma; COLLOIDS; FLOCCULATION
- Publication
British Journal of Haematology, 2004, Vol 126, Issue 5, p722
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/j.1365-2141.2004.05093.x