We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Limitations of Gallium-67 SPECT in histological transformation of chronic lymphocytic leukaemia: an analysis of 13 patients with clinically suspected Richter's syndrome.
- Authors
Cobo, Francesc; Rosiñol, Laura; Martínez, Antonio; Martín, Francisco; Esteve, Jordi; Gómez, Marta; Nadal, Elisabet; Bosch, Francesc; Javier Setoain, Francisco; Campo, Elías; Montserrat, Emili
- Abstract
Summary. Gallium-67 single photon emission computerized tomography (Ga-67 SPECT) was performed in 13 chronic lymphocytic leukaemia (CLL) patients suspected of evolution into diffuse large B-cell lymphoma (DLCL) or Richter's syndrome (RS). Six positive and nine negative Ga-67 SPECTs were observed. Ten patients were biopsied (five in each group). DLCL was not detected in any Ga-67-positive patient, including those in whom Ga-67-positive areas were biopsied. The only case of DLCL was demonstrated in a Ga-67-negative patient. The tumoral proliferative index (Ki67 antigen expression) was moderate and similar in both groups of patients. These results illustrate the limitations of Ga-67 SPECT in identifying RS.
- Subjects
CHRONIC lymphocytic leukemia; B cell lymphoma; TOMOGRAPHY
- Publication
British Journal of Haematology, 2002, Vol 119, Issue 2, p484
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1046/j.1365-2141.2002.03788.x