We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Proliferative Activity in Colonic Adenomas as a Predictor of Metachronous Adenomas as Assessed by Proliferating Cell Nuclear Antigen Immunohistochemistry.
- Authors
Paspatis, Gregorios A.; Karamanolis, Demetrios G.; Vasilakaki, Thivi; Zizi, Adamantia; Xourgias, Vasilios; Elemenoglou, Ioannis; Hadziyannis, Stephanos J.
- Abstract
Objectives: The aim of this study was to determine whether cell proliferation in colonic adenomas, as estimated by proliferating ceil nuclear antigen (PCNA), predicts the development of metachronous colonic adenomas. Methods: Forty patients who underwent prior endoscopic polypectomy for colonic adenomas were reevaluated by colonoscopy 2 yr later. The expression of PCNA was studied in all adenomas that were removed. A five-point semiquantitative scale of 1-5 was used to estimate the PCNA score by the percentage of positively stained cells. Results: Among the 40 patients studied, 16 developed recurrent adenomas (group A) and 24 were free of adenomas (group B). At initial colonoscopy, a total number of 51 adenomas (25 in group A and 26 in group B), were found. The median PCNA score in group A and group B index adenomas was 4 (interquartile range, 3-5) and 2 (interquartile range, 1-3), respectively (p < 0.01, Mann-Whitney U-test). A stepwise logistic regression analysis showed that PCNA score is a significant risk factor (p = 0.007, odds ratio 15.8, 95% confidence interval 2.2-112.4) in predicting adenoma recurrence. The median PCNA score in metachronous adenomas was 2 (interquartile range, 1-3). The difference in the PCNA score between group A index and metachronous adenomas was again statistically significant (p < 0.01, Mann-Whitney U-test). Conclusions: We conclude that the increased expression of PCNA in colonic adenomas may he a predictor for metachronous adenomas.
- Subjects
ADENOMA; CELL nuclei; CELL proliferation; COLON cancer; TUMORS; IMMUNOHISTOCHEMISTRY; COLONOSCOPY
- Publication
American Journal of Gastroenterology (Springer Nature), 1995, Vol 90, Issue 4, p597
- ISSN
0002-9270
- Publication type
Article