We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Fibroblast Growth Factor-21, Leptin, and Adiponectin Responses to Acute Cold-Induced Brown Adipose Tissue Activation.
- Authors
Sun, Lijuan; Yan, Jianhua; Goh, Hui Jen; Govindharajulu, Priya; Verma, Sanjay; Michael, Navin; Sadananthan, Suresh Anand; Henry, Christiani Jeyakumar; Velan, S Sendhil; Leow, Melvin Khee-Shing
- Abstract
<bold>Background: </bold>Adipocyte-derived hormones play a role in insulin sensitivity and energy homeostasis. However, the relationship between circulating fibroblast growth factor 21 (FGF21), adipocytokines and cold-induced supraclavicular brown adipose tissue (sBAT) activation is underexplored.<bold>Objective: </bold>Our study aimed to investigate the relationships between cold-induced sBAT activity and plasma FGF21 and adipocytokines levels in healthy adults.<bold>Design: </bold>Nineteen healthy participants underwent energy expenditure (EE) and supraclavicular infrared thermography (IRT) within a whole-body calorimeter at baseline and at 2 hours post-cold exposure. 18F-fluorodeoxyglucose (18F-FDG) positron-emission tomography/magnetic resonance (PET/MR) imaging scans were performed post-cold exposure. PET sBAT mean standardized uptake value (SUV mean), MR supraclavicular fat fraction (sFF), anterior supraclavicular maximum temperature (Tscv max) and EE change (%) after cold exposure were used to quantify sBAT activity.<bold>Main Outcome Measures: </bold>Plasma FGF21, leptin, adiponectin, and tumor necrosis factor alpha (TNFα) at baseline and 2 hours post-cold exposure. Body composition at baseline by dual-energy x-ray absorptiometry (DXA).<bold>Results: </bold>Plasma FGF21 and adiponectin levels were significantly reduced after cold exposure in BAT-positive subjects but not in BAT-negative subjects. Leptin concentration was significantly reduced in both BAT-positive and BAT-negative participants after cold exposure. Adiponectin concentration at baseline was positively strongly associated with sBAT PET SUV mean (coefficient, 3269; P = 0.01) and IRT Tscv max (coefficient, 6801; P = 0.03), and inversely correlated with MR sFF (coefficient, -404; P = 0.02) after cold exposure in BAT-positive subjects but not in BAT-negative subjects.<bold>Conclusion: </bold>Higher adiponectin concentrations at baseline indicate a greater cold-induced sBAT activity, which may be a novel predictor for sBAT activity in healthy BAT-positive adults.<bold>Highlights: </bold>A higher adiponectin concentration at baseline was associated with higher cold-induced supraclavicular BAT PET SUV mean and IRT Tscv max, and lower MR supraclavicular FF. Adiponectin levels maybe a novel predictor for cold-induced sBAT activity.
- Subjects
FLUORODEOXYGLUCOSE F18; BROWN adipose tissue; ADIPONECTIN; LEPTIN; ADIPOKINES; FIBROBLAST growth factors; DUAL-energy X-ray absorptiometry; INSULIN resistance
- Publication
Journal of Clinical Endocrinology & Metabolism, 2020, pN.PAG
- ISSN
0021-972X
- Publication type
journal article
- DOI
10.1210/clinem/dgaa005