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- Title
A randomized controlled trial of vitamin E and selenium on rate of decline in lung function.
- Authors
Cassano, Patricia A.; Guertin, Kristin A.; Kristal, Alan R.; Ritchie, Kathryn E.; Bertoia, Monica L.; Arnold, Kathryn B.; Crowley, John J.; Hartline, JoAnn; Goodman, Phyllis J.; Tangen, Catherine M.; Minasian, Lori M.; Lippman, Scott M.; Klein, Eric
- Abstract
Background: The intake of nutrients with antioxidant properties is hypothesized to augment antioxidant defenses, decrease oxidant damage to tissues, and attenuate age-related rate of decline in lung function. The objective was to determine whether long-term intervention with selenium and/or vitamin E supplements attenuates the annual rate of decline in lung function, particularly in cigarette smokers. Methods: The Respiratory Ancillary Study (RAS) tested the single and joint effects of selenium (200 µg/d L-selenomethionine) and vitamin E (400 IU/day all rac-α-tocopheryl acetate) in a randomized double-blind placebocontrolled trial. At the end of the intervention, 1,641 men had repeated pulmonary function tests separated by an average of 3 years. Linear mixed-effects regression models estimated the effect of intervention on annual rate of decline in lung function. Results: Compared to placebo, intervention had no main effect on either forced expiratory volume in the first second (FEV1) or forced expiratory flow (FEF25-75). There was no evidence for a smoking by treatment interaction for FEV1, but selenium attenuated rate of decline in FEF25-75 in current smokers (P = 0.0219). For current smokers randomized to selenium, annual rate of decline in FEF25-75 was similar to the annual decline experienced by never smokers randomized to placebo, with consistent effects for selenium alone and combined with vitamin E. Conclusions: Among all men, there was no effect of selenium and/or vitamin E supplementation on rate of lung function decline. However, current smokers randomized to selenium had an attenuated rate of decline in FEF25-75, a marker of airflow.
- Subjects
RANDOMIZED controlled trials; VITAMIN E; FAT-soluble vitamins; SELENIUM; LUNG physiology
- Publication
Respiratory Research, 2015, Vol 16, Issue 1, p1
- ISSN
1465-9921
- Publication type
Article
- DOI
10.1186/s12931-015-0195-5