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- Title
Effect of Korean Herbal Medicine Combined with a Probiotic Mixture on Diarrhea-Dominant Irritable Bowel Syndrome: A Double-Blind, Randomized, Placebo-Controlled Trial.
- Authors
Seok-Jae Ko; Gajin Han; Seul-Ki Kim; Jae-Gu Seo; Won-Seok Chung; Bongha Ryu; Jinsung Kim; Inkwon Yeo; Beom-Joon Lee; Jin-Moo Lee; Jae-Woo Park
- Abstract
Introduction. Although combination therapy with herbal medicine and probiotics is gaining popularity for controlling diarrhea-dominant irritable bowel syndrome (D-IBS) symptoms, few studies have investigated its clinical effects. Materials and Methods. Fifty-three patients with D-IBS were randomly allocated into 1 of the following 4 groups: herbal medicine (Gwakhyangjeonggisan; GJS) plus probiotics (Duolac 7S; DUO), GJS plus placebo DUO, placebo GJS plus DUO, and placebo GJS plus placebo DUO. The study period consisted of a 2-week run-in, 8 weeks of administration, and 2 weeks of follow-up. The primary outcomes were weekly adequate relief (AR) of overall IBS symptoms and the proportion of responders (PR) during the administration period. The secondary outcomes included individual IBS symptoms, stool assessment, and quality of life. Changes of intestinal microbiota and intestinal permeability were also analyzed. Results and Discussion. Weekly AR was not different among the 4 groups throughout the treatment period. However, the 3 treatment groups exhibited significant improvements in PR compared to the findings in the placebo group. In the intestinal microbiota assessment, herbal medicine and probiotics synergistically increased beneficial bacteria counts. Conclusion. Combination therapy with herbal medicine and probiotics appears to relieve overall IBS symptoms by synergistically increasing beneficial intestinal microbe counts.
- Subjects
SOUTH Korea; GUT microbiome; THERAPEUTIC use of plant extracts; THERAPEUTIC use of probiotics; ANALYSIS of variance; CHI-squared test; STATISTICAL correlation; DIARRHEA; FISHER exact test; IRRITABLE colon; HEALTH outcome assessment; PLACEBOS; QUALITY of life; RESEARCH funding; STATISTICAL sampling; SCALE analysis (Psychology); PLANT extracts; RANDOMIZED controlled trials; PROBIOTICS; VISUAL analog scale; TREATMENT effectiveness; BLIND experiment; SEVERITY of illness index; DATA analysis software; DIARY (Literary form)
- Publication
Evidence-based Complementary & Alternative Medicine (eCAM), 2013, Vol 2013, p1
- ISSN
1741-427X
- Publication type
Article
- DOI
10.1155/2013/824605