We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Role of the ubiquitin system and tumor viruses in AIDS-related cancer.
- Authors
Shackelford, Julia; Pagano, Joseph S.
- Abstract
Tumor viruses are linked to approximately 20% of human malignancies worldwide. This review focuses on examples of human oncogenic viruses that manipulate the ubiquitin system in a subset of viral malignancies; those associated with AIDS. The viruses include Kaposi's sarcoma herpesvirus, Epstein-Barr virus and human papilloma virus, which are causally linked to Kaposi's sarcoma, certain B-cell lymphomas and cervical cancer, respectively. We discuss the molecular mechanisms by which these viruses subvert the ubiquitin system and potential viral targets for anti-cancer therapy from the perspective of this system. Publication history: Republished from Current BioData's Targeted Proteins database (TPdb; http://www.targetedproteinsdb.com).
- Subjects
PUBLISHED reprints; UBIQUITIN; ONCOGENIC viruses; AIDS malignancies; KAPOSI'S sarcoma
- Publication
BMC Biochemistry, 2007, Vol 8, p1
- ISSN
1471-2091
- Publication type
Article
- DOI
10.1186/1471-2091-8-S1-S8