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- Title
Delayed treatment of MS is associated with high CSF levels of IL-6 and IL-8 and worse future disease course.
- Authors
Stampanoni Bassi, Mario; Iezzi, Ennio; Landi, Doriana; Monteleone, Fabrizia; Gilio, Luana; Simonelli, Ilaria; Musella, Alessandra; Mandolesi, Georgia; De Vito, Francesca; Furlan, Roberto; Finardi, Annamaria; Marfia, Girolama A.; Centonze, Diego; Buttari, Fabio
- Abstract
Background: Clinical deterioration of relapsing-remitting MS (RR-MS) patients reflects not only the number and severity of overt inflammatory and demyelinating episodes, but also subtle central damage caused by persistent exposure to inflammatory molecules.Objective: To explore the correlation between levels of CSF inflammatory molecules at the time of diagnosis and both demographic and clinical characteristics of a large sample of RR-MS patients, as well as the predictive value of cytokine levels on their prospective disease course.Methods: In 205 patients diagnosed with RR-MS, we measured at the time of diagnosis the CSF levels of inflammatory molecules. Clinical and MRI evaluation was collected at the time of CSF withdrawal and during a median follow-up of 3 years.Results: The time interval between the first anamnestic episode of focal neurological dysfunction and RR-MS diagnosis was the main factor associated with high CSF levels of IL-6 and IL-8. Furthermore, elevated CSF levels of these cytokines correlated with enhanced risk of clinical and radiological disease reactivation, switch to second-line treatments, and with disability progression in the follow-up.Conclusions: Delayed diagnosis and treatment initiation are associated with higher CSF levels of IL-6 and IL-8 in RR-MS, leading to worsening disease course and poor response to treatments.
- Subjects
MULTIPLE sclerosis treatment; DISEASE relapse prevention; CYTOKINES; NEUROLOGICAL disorders; INTERLEUKIN-6; INTERLEUKIN-8
- Publication
Journal of Neurology, 2018, Vol 265, Issue 11, p2540
- ISSN
0340-5354
- Publication type
Article
- DOI
10.1007/s00415-018-8994-5