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- Title
Inflammatory changes in the lungs of premature infants with symptomaticpatent ductus arteriosus.
- Authors
Nakamura, Toshihiko; Takasaki, Jiro; Ogawa, Yunosuke
- Abstract
Background: The aim of the study was to observethe inflammatory changes during the therapy for symptomatic patentductus arteriosus (sPDA). Methods: We investigated biochemically the sampleof the tracheobroncheal aspirates (TA) from 11 intubated prematureinfants. Three i.v. doses of indomethacin (0.2 mg/kg)were administered with 24-h intervals. The samples were dividedinto two groups, the effective occasions (n = 10)and non-effective occasions (n = 6). Theamounts of myeloperoxidase (MPO), soluble L-selectin (sL-selectin)in TA, and the polymorphonuclear leukocytes (PMN) of peripheralblood stream and TA were analyzed before and after treatment ofsPDA with indomethacin. Results: In effective occasions, there were significantdecreases of peripheral PMN and MPO and PMN in TA. However, thisgroup had a significant increase of sL-selectin. In non-effectiveoccasions, five out of six samples had decreases of MPO and PMNin TA, but not significantly. In contrast, there was a significant decreaseof sL-selectin. Conclusion: These data suggested that anti-inflammatorychange after closure of sPDA may be caused by not only indomethacinitself, but also ductal closure itself. However, futher study isnecessary to clarify the relationship between the closure of theductus itself and anti-inflammatory action in the lung.
- Subjects
LUNG diseases; PREMATURE infant diseases; PATENT ductus arteriosus
- Publication
Pediatrics International, 2002, Vol 44, Issue 4, p363
- ISSN
1328-8067
- Publication type
Article
- DOI
10.1046/j.1442-200X.2002.01588.x