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- Title
Sublimation-like behavior of cardiac dynamics in heart failure: A malignant phase transition?
- Authors
Goldberger, Ary L.; Henriques, Teresa S.; Mariani, Sara
- Abstract
An abrupt transition from sinus rhythm to atrial fibrillation (AF) is common in patients with chronic heart failure (CHF). We propose a conceptual framework for viewing this malignant transition in terms of a type of sublimation marked by the switch from highly periodic sinus interbeat interval dynamics characteristic of CHF to a state of random disorganization with AF. Sublimation of physical substances involves an increase in entropy via heat transfer. In contrast, the disease-related sublimation-like behavior involves a loss of information content, associated decreases in cardiac bioenergetic capacity and in multiscale entropy. © 2016 Wiley Periodicals, Inc. Complexity 21: 24-32, 2016
- Subjects
ATRIAL fibrillation risk factors; HEART failure
- Publication
Complexity, 2016, Vol 21, p24
- ISSN
1076-2787
- Publication type
Article
- DOI
10.1002/cplx.21811